Vibunazole (BAY-N-7133) |
Catalog No.GC32321 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 80456-55-9
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Animal experiment: | Under pentobarbital anesthesia 26 to 30 g female Swiss-Webster albino mice are injected intratracheally with either 0.05 mL sterile 0.9 % NaCI solution or 150 arthroconidia of Coccidioides imrnitis (strain Silveira) suspended in 0.05 mL of 0.9 % NaCI solution. Treatment of cohorts of ten infected and ten uninfected mice is begun 72 h after inoculation. Daily i.v. injections (tail vein) of 0.1 mL of 5 % glucose solution delivering either 0, 2.5, 5 or 10 mg/kg/dose of Vibunazole are given for 30 days[1]. |
References: [1]. Hoeprich PD, et al. Activity of BAY n 7133 and BAY 1 9139 in vitro and in experimental murine coccidioidomycosis. Eur J Clin Microbiol. 1985 Aug;4(4):400-3. |
Vibunazole is a new antifungal azole.
Vibunazole is an antifungal azole. Low concentrations of all three drugs inhibit Coccidioides immitis, strain Silveira, in vitro with a descending order of activity ketoconazole>Vibunazole>BAY 1 9139[1].
The untreated, infected mice lost weight initially and progressively, whereas treated mice gain weight after an initial loss with Vibunazole (all doses), BAY 1 9139 and ketoconazole at 2.5 mg/kg/day. With both Vibunazole and BAY 1 9139, the 5 and 10 mg/kg doses yield serum concentrations exceeding the MICs for the Coccidioides immitis test strain (0.8 and 1.5 μg/mL respectively) for periods in excess of 30 min after injection[1].
[1]. Hoeprich PD, et al. Activity of BAY n 7133 and BAY 1 9139 in vitro and in experimental murine coccidioidomycosis. Eur J Clin Microbiol. 1985 Aug;4(4):400-3.
Cas No. | 80456-55-9 | SDF | |
Canonical SMILES | OC(C(C)(C)C)(COC1=CC=C(Cl)C=C1)CN2N=CN=C2 | ||
Formula | C15H20ClN3O2 | M.Wt | 309.79 |
Solubility | Soluble in DMSO | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 3.228 mL | 16.14 mL | 32.2799 mL |
5 mM | 0.6456 mL | 3.228 mL | 6.456 mL |
10 mM | 0.3228 mL | 1.614 mL | 3.228 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
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