Vitamin A Acetate (Synonyms: NSC 122045, NSC 122760, Ro 1-5275, Vitamin A Acetate) |
| Catalog No.GC14506 |
Vitamin A Acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 127-47-9
Sample solution is provided at 25 µL, 10mM.
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Vitamin A acetate (also known as retinyl acetate) is a fatty acid ester form of vitamin A with antineoplastic and chemopreventive effect. Retinyl acetate activated retinoid receptor to induce cell differentiation and decrease cell proliferation. It also exhibited immunomodulatory properties and blocks carcinogen-induced neoplastic transformation.
Retinoid receptors mediate retinoids activities and involved in normal growth and development maintenance, immune response and reproduction.
In rat renal glomerular epithelial cells, retinyl acetate modulated growth, morphology, function and cell organization. [1]
By supplementing normal diet with retinyl acetate in newborn CBA mice of lymphoid cells from (CBA X C57BL/10ScSn) F1 hybrids increased the proportion of the T-cell moiety population that generated IL-2. [2] In Sprague-Dawley rats, chemoprotective properties of retinyl acetate and combination of RA with Mel were demonstrated in mammary carcinogenesis activated by DMBA. [3]
References:
[1] Yamada M, Moritoh C, Kawaguchi M, Okigaki T. Growth, morphology, function, and morphogenetic properties of rat renal glomerular epithelial cells in vitro: effects of retinyl acetate. Eur J Cell Biol. 1989 Aug;49(2):252-8.
[2] Malkovský M, Medawar PB, Thatcher DR, Toy J, Hunt R, Rayfield LS, Doré C. Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate. Proc Natl Acad Sci U S A. 1985 Jan;82(2):536-8.
[3] Hlersová E, Ahlers I, Kubatka P, Bojková B, Môciková K, Gajdosová S, Onderková HM. Melatonin and retinyl acetate as chemopreventives in DMBA-induced mammary carcinogenesis in female Sprague-Dawley rats. Folia Biol (Praha). 2000;46(2):69-72.
| Cas No. | 127-47-9 | SDF | |
| Synonyms | NSC 122045, NSC 122760, Ro 1-5275, Vitamin A Acetate | ||
| Chemical Name | [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate | ||
| Canonical SMILES | CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCOC(=O)C)C)C | ||
| Formula | C22H32O2 | M.Wt | 328.49 |
| Solubility | ≥ 16.8mg/mL in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0442 mL | 15.2212 mL | 30.4423 mL |
| 5 mM | 608.8 μL | 3.0442 mL | 6.0885 mL |
| 10 mM | 304.4 μL | 1.5221 mL | 3.0442 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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