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VP-14637

Catalog No.GC11893

inhibitor of RSV

Products are for research use only. Not for human use. We do not sell to patients.

VP-14637 Chemical Structure

Cas No.: 235106-62-4

Size Price Stock Qty
1mg
$87.00
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5mg
$297.00
In stock
10mg
$505.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

EC50: 5.4 nM for RSV fusion

VP-14637 is an inhibitor of RSV.

Respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. RSV F protein that mediates fusion of the viral envelope with the host cell membrane has become a target of anti-RSV treatment.

In vitro: Previous study demonstrated that VP-14637 did not block RSV adsorption but inhibited RSV-induced cell-cell fusion and specifically bound to RSV-infected cells. VP-14637 was capable of specifically interacting with the RSV fusion protein. RSV variants resistant to VP-14637 were selected, in which no mutations arose in HR1, indicating a mechanism other than direct disruption of the heptad repeat interaction. The F proteins containing the resistance mutations exhibited greatly reduced binding of VP-14637 [1].

In vivo: In cotton rats, animals given as little as 126 microg/kg of VP-14637 by small droplet aerosol starting 1 day after experimental virus infection with either a RSV A or B subtype consistently had significantly lower mean pulmonary RSV titers and reduced histopathological findings than mock-treated animals or cotton rats given placebo. In addition, no cotton rat treated with VP14637 had any evident untoward responses [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Douglas, J. L.,Panis, M.L.,Ho, E., et al. Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein. Journal of Virology 77(9), 5054-5064 (2003).
[2] Wyde PR, Laquerre S, Chetty SN, Gilbert BE, Nitz TJ, Pevear DC.  Antiviral efficacy of VP14637 against respiratory syncytial virus in vitro and in cotton rats following delivery by small droplet aerosol. Antiviral Res. 2005 Oct;68(1):18-26.

Chemical Properties

Cas No. 235106-62-4 SDF
Chemical Name 2,2’-[(4-hydroxyphenyl)methylene]bis[4-[[(5-methyl-1H-tetrazol-1-yl)imino]methyl]-phenol
Canonical SMILES OC1=CC=C(C(C2=CC(/C=N/N3C(C)=NN=N3)=CC=C2O)C4=CC(/C=N\N5N=NN=C5C)=CC=C4O)C=C1
Formula C25H22N10O3 M.Wt 510.5
Solubility ≤10mg/ml in ethanol;10mg/ml in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.9589 mL 9.7943 mL 19.5886 mL
5 mM 0.3918 mL 1.9589 mL 3.9177 mL
10 mM 0.1959 mL 0.9794 mL 1.9589 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 16 reference(s) in Google Scholar.)

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