WAY 316606 hydrochloride |
| Catalog No.GC50077 |
Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1781835-02-6
Sample solution is provided at 25 µL, 10mM.
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Secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay. We are aware of a study in PLOS Biology where WAY-316606 was found to stimulate hair follicle growth. Please note that WAY-316606 is for laboratory research use only, and that we will only sell to established scientific businesses and institutes.
References:
[1]Moore et al (2010) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 18 190 PMID:19932972
[2]Moore et al (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 52 105 PMID:19072540
[3]Bodine et al (2009) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 44 1063 PMID:19254787
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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