YIL 781 hydrochloride |
| Catalog No.GC50049 |
Ghrelin receptor (GHS-R1a) antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1640226-17-0
Sample solution is provided at 25 µL, 10mM.
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Ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). Displays no significant affinity for the motilin receptor (Ki = 6 μM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo.
Esler et al (2007) Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148 5175 PMID:17656463 |Moran and Dailey (2009) Gut peptides: targets for antiobesity drug development• Endocrinology 150 2526 PMID:19372201
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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