|Z-Guggulsterone Catalog No.GC10195|
Sample solution is provided at 25 µL, 10mM.
GlpBio Products Cited In Reputable Papers
|Canonical SMILES||O=C1C[[email protected]]([[email protected]@](/C1=C/C)(C)CC2)[[email protected]@H](CC3)[[email protected]@H]2[[email protected]](CC4)(C)C3=CC4=O|
|Solubility||≥ 3.12mg/mL in DMSO with ultrasonic and warming||Storage||Store at RT|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.
Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC.
Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight.
. Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80.