Home>>Signaling Pathways>> Others>> Heme oxygenase>>Zinc protoporphyrin IX

Zinc protoporphyrin IX

Catalog No.GC11208

Zinc protoporphyrin IX Chemical Structure

heme oxygenase inhibitor

Size Price Stock Qty
10mM * 1mL in DMSO
In stock
In stock
In stock
In stock
In stock
In stock

Customer Reviews

Based on customer reviews.

Tel: (626) 353-8530 Email: sales@glpbio.com

Sample solution is provided at 25 µL, 10mM.

Product Citations

Quality Control

Quality Control & SDS

View current batch:


Zinc protoporphyrin-9 (ZnPPIX) is an endogenous metabolite formed during heme biosynthesis under conditions of iron insufficiency or impaired iron utilization.[1] It also regulates heme catabolism through competitive inhibition of heme oxygenase, the rate-limiting enzyme in the heme degradation pathway that produces bilirubin and carbon monoxide.[1] ZnPPIX has been shown to inhibit 80% of soluble guanylyl cyclase basal activity at 2.5 μM and to inactivate the NOS isoforms nNOS, iNOS, and eNOS with IC50 values of 0.8, 4, and 5 μM, respectively.[2],[3] ZnPPIX has been used to assess iron status and to diagnose iron disorders and has shown therapeutic potential in hyperbilirubinemia.[1]

[1]. Labbé, R.F., Vreman, H.J., and Stevenson, D.K. Zinc protoporphyrin: A metabolite with a mission. Clinical Chemistry 45(12), 2060-2072 (1999).
[2]. Serfass, L., and Burstyn, J.N. Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity. Archives of Biochemistry and Biophysics 359(1), 8-16 (1998).
[3]. Wolff, D.J., Naddelman, R.A., Lubeskie, A., et al. Inhibition of nitric oxide synthase isoforms by porphyrins. Archives of Biochemistry and Biophysics 333(1), 27-34 (1996).

Chemical Properties

Cas No. 15442-64-5 SDF
Synonyms ZnPPIX
Chemical Name zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
Canonical SMILES OC(CCC1=C(C)/C([N-]/C1=C\2)=C/C(C(C)=C/3C=C)=NC3=C/C4=N/C(C(C=C)=C4C)=C\C5=C(C)C(CCC(O)=O)=C2[N-]5)=O.[Zn+2]
Formula C34H32N4O4Zn M.Wt 626.03
Solubility DMF: 14 mg/ml,DMSO: 25 mg/ml,DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml Storage Store at -20°C, sealed storage, away from moisture
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

  • Molarity Calculator

  • Dilution Calculator

**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).



Review for Zinc protoporphyrin IX

Average Rating: 5 ★★★★★ (Based on Reviews and 37 reference(s) in Google Scholar.)

5 Star
4 Star
3 Star
2 Star
1 Star
Review for Zinc protoporphyrin IX

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.