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Zinc protoporphyrin IX

Catalog No.GC11208

Zinc protoporphyrin IX Chemical Structure

heme oxygenase inhibitor

Size Price Stock Qty
10mM * 1mL in DMSO
$316.00
In stock
1mg
$59.00
In stock
5mg
$230.00
In stock
10mg
$338.00
In stock
25mg
$675.00
In stock
50mg
$945.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Background

Zinc protoporphyrin-9 (ZnPPIX) is an endogenous metabolite formed during heme biosynthesis under conditions of iron insufficiency or impaired iron utilization.[1] It also regulates heme catabolism through competitive inhibition of heme oxygenase, the rate-limiting enzyme in the heme degradation pathway that produces bilirubin and carbon monoxide.[1] ZnPPIX has been shown to inhibit 80% of soluble guanylyl cyclase basal activity at 2.5 μM and to inactivate the NOS isoforms nNOS, iNOS, and eNOS with IC50 values of 0.8, 4, and 5 μM, respectively.[2],[3] ZnPPIX has been used to assess iron status and to diagnose iron disorders and has shown therapeutic potential in hyperbilirubinemia.[1]

Reference:
[1]. Labbé, R.F., Vreman, H.J., and Stevenson, D.K. Zinc protoporphyrin: A metabolite with a mission. Clinical Chemistry 45(12), 2060-2072 (1999).
[2]. Serfass, L., and Burstyn, J.N. Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity. Archives of Biochemistry and Biophysics 359(1), 8-16 (1998).
[3]. Wolff, D.J., Naddelman, R.A., Lubeskie, A., et al. Inhibition of nitric oxide synthase isoforms by porphyrins. Archives of Biochemistry and Biophysics 333(1), 27-34 (1996).

Chemical Properties

Cas No. 15442-64-5 SDF
Synonyms ZnPPIX
Chemical Name zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
Canonical SMILES OC(CCC1=C(C)/C([N-]/C1=C\2)=C/C(C(C)=C/3C=C)=NC3=C/C4=N/C(C(C=C)=C4C)=C\C5=C(C)C(CCC(O)=O)=C2[N-]5)=O.[Zn+2]
Formula C34H32N4O4Zn M.Wt 626.03
Solubility DMF: 14 mg/ml,DMSO: 25 mg/ml,DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml Storage Store at -20°C, sealed storage, away from moisture
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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