7-Hydroxycoumarin glucuronide is a transport substrate and main human coumarin metabolite. [1] 7-Hydroxycoumarin glucuronide undergoes ATP-dependent efflux transport via MRP3 and MRP4. [1] 7-Hydroxycoumarin glucuronide undergoes active transport processes for urinary excretion and is primarily excreted into urine in humans. [1]
In Vitro, 7-Hydroxycoumarin glucuronide (400 μM; 10-20 min) is a substrate of MRP3 (Km = 187 μM) and MRP4 (Km = 63 μM) efflux transporters, but not of MRP1, MRP2, BCRP, or P-gp, as demonstrated by ATP-dependent uptake in MRP3- and MRP4-overexpressing membrane vesicles[1].
References:
[1]. Wittgen HG, et al. Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4. Drug Metab Dispos. 2012;40(6):1076-1079.
In Vitro, 7-Hydroxycoumarin glucuronide (400 μM; 10-20 min) is a substrate of MRP3 (Km = 187 μM) and MRP4 (Km = 63 μM) efflux transporters, but not of MRP1, MRP2, BCRP, or P-gp, as demonstrated by ATP-dependent uptake in MRP3- and MRP4-overexpressing membrane vesicles[1].
References:
[1]. Wittgen HG, et al. Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4. Drug Metab Dispos. 2012;40(6):1076-1079.