7-Methylguanosine 5’-diphosphate sodium (Synonyms: 7-Methyl-GDP sodium; m7GDP sodium) |
| Catalog No.GC62817 |
Le 7-méthylguanosine 5'-diphosphate (7-méthyl-GDP) sodium, un analogue de coiffe, peut être utilisé dans la synthèse d'analogues de coiffe d'ARNm.
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Cas No.: 104809-16-7
Sample solution is provided at 25 µL, 10mM.
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7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues[1].
7-Methylguanosine 5’-diphosphate sodium inhibits binding of eukaryotic initiation factors to reovirus capped mRNA and complex formation involving uncapped mRNA or 18 S rRNA[1].T. brucei mRNA decapping enzyme (TbDcp2) that cleaves 7-Methylguanosine 5’-diphosphate sodium from capped RNA to generate pRNA, a substrate for TbCe1[2].
[1]. Sonenberg N, et al. Nonspecific effect of m7GMP on protein-RNA interactions. J Biol Chem. 1978;253(19):6630-6632.
[2]. Ignatochkina AV, et al. The messenger RNA decapping and recapping pathway in Trypanosoma. Proc Natl Acad Sci U S A. 2015;112(22):6967-6972.
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