Acetyl-coenzyme A-d3 (acetyl-CoA-d3) is intended for use as an internal standard for the quantification of acetyl-CoA by GC- or LC-MS. Acetyl-CoA, the thioester of CoA and acetic acid, is a pivotal molecule in biological systems. Foremost, it serves as a source of carbon for the Krebs cycle, for the synthesis of fatty acids, and for isoprenoid-based protein modifications.1,2,3,4 Acetyl-CoA also serves as an intermediate in oxidation of fatty acids and amino acids and is formed by the oxidative decarboxylation of pyruvate in mitochondria.[5] It is an essential cofactor or substrate for acetyltransferases and acyltransferases, as in the post-translational modification of proteins and in the synthesis of the neurotransmitter acetylcholine.2,3
References:
[1].Akram, M.Citric acid cycle and role of its intermediates in metabolismCell Biochem. Biophys.68(3)475-478(2014).
[2].Salminen, A., Kauppinen, A., Hiltunen, M., et al.Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging processAgeing Res. Rev.16C45-65(2014).
[3].Zaidi, N., Swinnen, J.V., and Smans, K.ATP-citrate lyase: A key player in cancer metabolismCancer Res.72(15)3709-3714(2012).
[4].Palsson-McDermott, E.M., and O'Neill, L.A.The Warburg effect then and now: From cancer to inflammatory diseasesBioEssays35(11)965-973(2013).
[5].Miura, Y.The biological significance of ω-oxidation of fatty acidsProc. Jpn. Acad. Ser. B Phys. Biol. Sci.89(8)370-382(2013).