Gamma-Glu-Abu acetate is a CaSR activator with an EC 50 of 0.21 μM (in HEK-293 cells). Gamma-Glu-Abu acetate interacts with the extracellular venus flytrap domain of hCaSR via its N-terminal γ-L-glutamyl residue, the neutral aliphatic side chain of the Abu residue, and the C-terminal carboxylic acid group [1].
In Vitro, Gamma-Glu-Abu (0.1-1000 μM) acetate acts as an agonist of human CaSR in HEK-293 cells, with an EC50 of 0.21 μM[1].
References:
[1]. Amino Y, et al. Structure-CaSR-Activity Relation of Kokumi γ-Glutamyl Peptides. Chemical & pharmaceutical bulletin. 2016;64(8):1181-9.
In Vitro, Gamma-Glu-Abu (0.1-1000 μM) acetate acts as an agonist of human CaSR in HEK-293 cells, with an EC50 of 0.21 μM[1].
References:
[1]. Amino Y, et al. Structure-CaSR-Activity Relation of Kokumi γ-Glutamyl Peptides. Chemical & pharmaceutical bulletin. 2016;64(8):1181-9.