2,4鈥?Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4鈥?Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-魏B. 2,4鈥?Dihydroxybenzophenone is also a UV absorber.
2,4鈥?Dihydroxybenzophenone (6.25-25 渭M) reduces mortality and morphological abnormalities, restores heart rate, and mitigates macrophage and neutrophil recruitment to inflammatory sites in LPS-microinjected zebrafish larvae[1].
[1]. Kavinda MHD, et al. 2,4'-Dihydroxybenzophenone: A Promising Anti-Inflammatory Agent Targeting Toll-like Receptor 4/Myeloid Differentiation Factor 2-Mediated Mitochondrial Reactive Oxygen Species Production during Lipopolysaccharide-Induced Systemic Inflammation. ACS Pharmacol Transl Sci. 2024 Apr 27;7(5):1320-1334.
[2]. Fang Z, et al. Effect of Substituent Groups on the Strength of Intramolecular Hydrogen Bonds in 2,4-Dihydroxybenzophenone UV Absorbers. Molecules. 2023 Jun 27;28(13):5017.