Flunarizine blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 渭M and 1.77 渭M in cultured rat cortical neurons, respectively[2].
Flunarizine (10 and 30 渭M; 24 h) shows cytotoxic effects to chromaffin cells[4].
Flunarizine (1-30 渭M) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 渭M[4].
Flunarizine (intraperitoneal injection; 30鈥塵g/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI)[5].
[1]. Hong-Seob So, et al. Protective effect of T-type calcium channel blocker flunarizine on cisplatin-induced death of auditory cells. Hear Res. 2005 Jun;204(1-2):127-39.
[2]. Qing Ye, et al. Flunarizine blocks voltage-gated Na(+) and Ca(2+) currents in cultured rat cortical neurons: A possible locus of action in the prevention of migraine. Neurosci Lett. 2011 Jan 10;487(3):394-9.
[3]. Celia M Santi, et al. Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci. 2002 Jan 15;22(2):396-403.
[4]. Novalbos J, et al. Effects of dotarizine and flunarizine on chromaffin cell viability and cytosolic Ca2+. Eur J Pharmacol. 1999 Feb 5;366(2-3):309-17.
[5]. Wan L, et al. Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury. Mediators Inflamm. 2020 Nov 10;2020:3691701.