Prostaglandins

17,20-dimethyl PGF1α is an analog of the limaprost family with structural modifications intended to give it a prolonged half-life and greater potency.

Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.

The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor.

17-phenyl trinor 8-iso Prostaglandin E2 (17-phenyl trinor 8-iso PGE2) is the C-8 epimer of 17-phenyl trinor PGE2, a synthetic analog of PGE2.

17-phenyl trinor PGA2 is a synthetic prostaglandin analog designed for increased half-life and greater potency.

17-phenyl trinor Prostaglandin D2 (17-phenyl trinor PGD2) is a novel, chemically stable analog of PGD2 wherein the lower side chain is modified by the addition of a phenyl group at C-17 in place of the last 3 ω-chain carbon atoms.

17-phenyl trinor PGE2 is a synthetic analog of PGE2.

17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively).

17-phényl trinor Prostaglandine F2α l'amide est un métabolite N-déséthylé du bimatoprost.

17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable, potent agonist of the PGF (FP) receptor.

17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide.

Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis.

17-phenyl trinor Prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide.

17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.

17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α.

2-Arachidonyl glycerol (2-AG) exhibits cannabinoid agonist activity at the central cannabinoid (CB1) receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB1 receptor.

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.

Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.

Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.

Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.

19(R)-hydroxy PGF1α is an ω-1 hydroxylase metabolite of PGF1α that has been identified in the semen of humans and marsupials.

Fluprostenol is a well-studied, potent analog of PGF2α acting primarily through the FP receptor.

2,3-dinor-6-keto prostaglandin F1α (2,3-dinor-6-keto PGF1α) is the β-oxidation product of 6-keto PGF1α and the major urinary metabolite of PGI2 in humans.

L'acide 2-chloro palmitique, un médiateur lipidique inflammatoire, interfère avec la palmitoylation des protéines, induit des marqueurs de stress ER, réduit la teneur en ATP ER et active la transcription et la sécrétion d'IL-6 ainsi que d'IL-8.2-chloro L'acide palmitique perturbe la mitochondrie potentiel membranaire et induit le clivage de la procaspase-3 et de la PARP. L'acide palmitique 2-chloro peut traverser la barrière hémato-encéphalique (BBB) et compromettre les fonctions ER et mitochondriales dans la lignée cellulaire endothéliale du cerveau humain hCMEC/D3.