Myocardial Contractility

Le monodigitoxoside de digoxigénine est un inhibiteur de l'ATPase Na+/K+ et un métabolite glycoside cardiaque de la digoxine.

L'acétyldigitoxine (Digitoxin 3'''-Acetate) est un glycoside cardiaque.

Isolated neonatal rat cardiomyocytes, which spontaneously beat in culture, are used to evaluate the antiarrhythmic effects of polyunsaturated fatty acids (PUFA).

Le bisindolylmaléimide XI (chlorhydrate) (Ro 32-0432) est un inhibiteur de PKC puissant, sélectif et actif par voie orale avec des CI50 de 9 nM, 28 nM, 31 nM, 37 nM et 108 nM pour PKCα, PKCβI, PKCβII, PKCγ et PKCε , respectivement.

17(R),18(S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EpETE), a natural cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid, is known to reduce the contraction rate of spontaneously beating heart cells and to protect neonatal rat cardiomyocytes against arrhythmias induced by β-adrenergic agonists (EC50 = ~ 1-2 nM).

Milrinone-d3 is intended for use as an internal standard for the quantification of milrinone by GC- or LC-MS.

Le carbazeran, un puissant inhibiteur de la phosphodiestérase, est un substrat de l'aldéhyde oxydase.

Digitoxigenin is a cardenolide and aglycone constituent of digitoxin, an extract from the foxglove plant, D.

(±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.

4-hydroxy Nebivolol is a major metabolite of nebivolol.

5-hydroxy Saxagliptin is a major active metabolite of saxagliptin.

C2 Ceramide (d14:1/2:0) est une composition pour le diagnostic de maladies associées À la surexpression de la cyclooxygénase 2 (COX2). C2 Ceramide (d14:1/2:0) présente une forte activité de liaison À la protéine COX2 (extrait du brevet WO2019235824A1).

Doxorubicinol is the major metabolite of doxorubicin, an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks.

KR-32568 is an inhibitor of the sodium-hydrogen exchanger isoform-1 (NHE-1; IC50 = 230 nM).

Nebivolol O-β-D-glucuronide is an active metabolite of the β1-adrenergic receptor antagonist nebivolol.

Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.

Propranolol β-D-glucuronide is a major metabolite of propranolol.

rac-7-hydroxy Propranolol (hydrochloride) is a ring-hydroxylated isomer and metabolite of propranolol that is an antagonist at β-adrenergic receptors (0.95 potency relative to propranolol).

Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide.

Iohexol-d5 est Iohexol marqué au deutérium. Iohexol est un agent de contraste radiographique et peut être appliqué pour la myélographie, la tomographie informatisée(cisternographie, ventriculographie) et l'imagerie MicroCT in vivo.

A PDE3 inhibitor

A neuropeptide with diverse biological activities

An internal standard for the quantification of esmolol

An internal standard for the quantification of manidipine