Nucleic Acid Turnover/Signaling

Akt1, 2, and 3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.

8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents.

MST-312 est un inhibiteur puissant de la télomérase, sa valeur d'IC50 est 0,67μM.

β ; - L'amanitine est une toxine peptidique cyclique présente dans le champignon vénéneux Amanita phalloides. β ; - L'amanitine inhibe l'ARN polymérase eucaryote II et III. β ; - L'amanitine inhibe la synthèse des protéines. β-Amanitin peut être utilisé comme composant cytotoxique de conjugués anticorps-médicament (ADC).

Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S.

Ciprofloxacin-d8 is intended for use as an internal standard for the quantification of ciprofloxacin by GC- or LC-MS.

Tigecycline-d9 is intended for use as an internal standard for the quantification of tigecycline by GC- or LC-MS.

Dihydroresveratrol is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota.

La 6-aminophénanthridine inhibe l'activité de repliement des protéines du ribosome (PFAR).

Le (R)-gyramide A (chlorhydrate) est un inhibiteur de l'ADN gyrase bactérienne qui perturbe l'activité de surenroulement avec une valeur IC50 de 3,3 µM.

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS.

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.

9-Deazaguanine est un analogue de nucléoside purique possédant une activité par voie orale. Elle agit comme un inhibiteur puissant de la purine-nucléoside phosphorylase (PNP).

L'amétantrone (NSC 196473) est un agent antitumoral qui s'intercale dans l'ADN et induit une rupture de l'ADN médiée par la topoisomérase II (TOP2).

Le pemetrexed (sel de sodium hydraté) est un nouvel antifolate, les valeurs Ki du pentaglutamate de LY231514 sont de 1,3, 7,2 et 65 nM pour inhiber la thymidylate synthase (TS), la dihydrofolate réductase (DHFR) et la glycinamide ribonucléotide formyltransférase (GARFT), respectivement .

Trimethoprim is an antibiotic that inhibits dihydrofolate reductase (DHFR) and shows selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).

An internal standard for quantifying doxycycline

An internal standard for the quantification of docosanoic acid

A neuropeptide with diverse biological activities

A neuropeptide with diverse biological activities

A protein synthesis inhibitor with diverse biological activities

A cGAS inhibitor

A cGAS inhibitor

A neuropeptide with diverse biological activities