P110 (trifluoroacetate salt)

P110 is a peptide inhibitor of the mitochondrial GTPase dynamin-related protein 1 (DRP1).¹ It selectively inhibits DRP1 GTPase activity over the additional mitochondrial GTPases OPA1, MFN1, and dynamin 1 at 1 µM. P110 (1 µM) inhibits the MPP⁺-induced protein-protein interaction between DRP1 and mitochondrial fission 1 (FIS1), as well as MPP⁺-, carbonyl cyanide M-chloro phenyl drazone-, rotenone-, or drogen peroxide-induced DRP1 translocation to the mitochondria in SH-SY5Y cells. It also inhibits MPP⁺-induced mitochondrial apoptosis and autophagy in SH-SY5Y cells and MPP⁺-induced mitochondrial fragmentation and cell death in a primary rat dopaminergic neuronal model of Parkinson’s disease.