Z-Ala-OSu is an alanine derivative with N-hydroxysuccinimide ester [1]. Z-Ala-OSu can react with Ala-NHPro-Val-Ala-Ala-NH HCl at room temperature for 60 hours to form hydrazinopeptides [2]. Z-Ala-OSu can be used as a starting material for the synthesis of Z-Ala-Ala-NH2 and related polypeptide chains[3].
References:
[1] Wallace D A, Bates S R, Walker B, et al. Competitive inhibition of human skin collagenase by N-benzyloxycarbonyl-L-prolyl-L-alanyl-3-amino-2-oxopropyl-L-leucyl-L-alanylglycine ethyl ester[J]. Biochemical Journal, 1986, 239(3): 797.
[2] Guy L, Vidal J, Collet A, et al. Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors[J]. Journal of medicinal chemistry, 1998, 41(24): 4833-4843.
[3] Katakai R, Oya M, Toda F, et al. A Novel Synthesis of Sequential Polypeptides[J]. Macromolecules, 1973, 6(6): 827-831.