1α-Hydroxy-3-epi-vitamin D3 |
| カタログ番号GC62761 |
1α-ヒドロキシ-3-エピ-ビタミン D3 は、1α,25-ジヒドロキシビタミン D3 の天然代謝産物であり、副甲状腺ホルモン (PTH) 分泌の強力なサプレッサーです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 58028-00-5
Sample solution is provided at 25 µL, 10mM.
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1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion[1].
1 alpha, 25(OH)2D3 is an important negative regulator of parathyroid hormone (PTH) gene transcription[1]. In ROS 17/2.8 cells, 1α-OHD3 (10 μM) not only metabolized into 1αOH-3-epi-D3 and 1α,25(OH)2D3 but also 1α,25(OH)2-3-epi-D3[2].
[1]. A J Brown, et al. 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone secretion. J Cell Biochem. 1999 Apr 1;73(1):106-13.
[2]. Alex J Brown, et al. Isolation and identification of 1alpha-hydroxy-3-epi-vitamin D3, a potent suppressor of parathyroid hormone secretion. J Cell Biochem
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