AB-680 |
| カタログ番号GC65293 |
AB-680 は、CD73 (エクトヌクレオチダーゼ) の非常に強力で可逆的かつ選択的な阻害剤であり、hCD73 に対して 4.9 pM の Ki を持ち、関連するエクトヌクレオチダーゼ CD39 よりも >10,000 倍の選択性を示します。抗腫瘍活性。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2105904-82-1
Sample solution is provided at 25 µL, 10mM.
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AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].
AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].
[1]. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.
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