Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems[1][2].
Abacavir hydroxyacetate (10-20 mg/kg; p.o. once) effectively controls psoriasis of mice[2].
| Animal Model: | 6 to 8-week-old male and female SCID mice with implantation of psoriatic tissue[2] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | Oral gavage; 10-20 mg/kg once |
| Result: | Decreased the concentration of PRINS and 1L-20, and reduced the lesion area of skin. Showed a better effect than methotrexate in controlling psoriasis. |