Abraxane (Synonyms: Nab-Paclitaxel) |
カタログ番号GC25025
One-Click Copy Product Info
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アブラキサン（Nab-Paclitaxel）は、Paclitaxelと人血清アルブミンの結合比率が1：9である新しい溶媒フリーのタキサンであり、マイクロチューブル凝集を促進する抗マイクロチューブル薬剤です。これにより、チューブリン二量体内でマイクロチューブルの解重合を阻害して、マイクロチューブルシステムを安定化させます。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.
Treating human pancreatic ductal adenocarcinoma cells first with gemcitabine followed by Abraxane (Nab-Paclitaxel) at 48 hours is found to have the greatest inhibition of cell growth.[3]
In mice with human pancreatic cancer xenografts, nab-paclitaxel alone and in combination with gemcitabine deplete the desmoplastic stroma. The intratumoral concentration of gemcitabine is increased by 2.8-fold in mice receiving nab-paclitaxel plus gemcitabine versus those receiving gemcitabine alone.[4]
[1] Yardley DA, et al. Epub 2013 Jun 11. [2] Lluch A, et al. Crit Rev Oncol Hematol. 2014 Jan;89(1):62-72. [3] Wolfe AR, et al. Clin Cancer Res. 2021 Jan 15;27(2):554-565.
| Cas No. | SDF | ||
| 同義語 | Nab-Paclitaxel | ||
| Formula | C47H51NO14 | M.Wt | 853.91 |
| 溶解度 | Storage | 4°C,do not freeze. | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.1711 mL | 5.8554 mL | 11.7108 mL |
| 5 mM | 234.2 μL | 1.1711 mL | 2.3422 mL |
| 10 mM | 117.1 μL | 585.5 μL | 1.1711 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
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Purity: >99.5%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)