Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer.
Ac-PLVE-FMK can efficiently inhibit the activity of Cat-B and Cat-L in the target-based assay (human recombinant enzymes) [1].Ac-PLVE-FMK can penetrate the cell membrane in the cell-based assay on two human renal cancer cell lines (769-P and A498) [1].
References:
[1]. Citarella A, et al. Peptidyl Fluorometl Ketones and Their Applications in Medicinal Chemistry. Molecules. 2020;25(17):4031. Published 2020 Sep 3.