Anti-Mouse CD3ε Antibody (KT3) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse CD3ε. Anti-Mouse CD3ε Antibody (KT3) increases thymocytes proliferation. Anti-Mouse CD3ε Antibody (KT3) can be used for the research of immunology [1] [2] [3].
In Vivo, Anti-Mouse CD3ε Antibody (KT3) (10 μg, i.v.) induces preferential death and Fas-L expression in γδ T cells in mice[3].
In Vitro, Anti-Mouse CD3ε Antibody (KT3) (72 h) increases T-cell receptor-triggered proliferation in thymocytes[1]. Anti-Mouse CD3ε Antibody (KT3) (1 μg/mL, 30 mins) exhibits impaired Ca2+ fluxes in thymocytes and mature lymph node T cells[2].
References:
[1]. Hueber AO, et al. Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation. Curr Biol. 1997 Sep 1;7(9):705-8.
[2]. Fischer KD, et al. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol. 1998 May 7;8(10):554-62.
[3]. Mukasa A, et al. Extensive and preferential Fas/Fas ligand-dependent death of gammadelta T cells following infection with Listeria monocytogenes. Scand J Immunol. 2002 Sep;56(3):233-47.
In Vivo, Anti-Mouse CD3ε Antibody (KT3) (10 μg, i.v.) induces preferential death and Fas-L expression in γδ T cells in mice[3].
In Vitro, Anti-Mouse CD3ε Antibody (KT3) (72 h) increases T-cell receptor-triggered proliferation in thymocytes[1]. Anti-Mouse CD3ε Antibody (KT3) (1 μg/mL, 30 mins) exhibits impaired Ca2+ fluxes in thymocytes and mature lymph node T cells[2].
References:
[1]. Hueber AO, et al. Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation. Curr Biol. 1997 Sep 1;7(9):705-8.
[2]. Fischer KD, et al. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol. 1998 May 7;8(10):554-62.
[3]. Mukasa A, et al. Extensive and preferential Fas/Fas ligand-dependent death of gammadelta T cells following infection with Listeria monocytogenes. Scand J Immunol. 2002 Sep;56(3):233-47.