Aureonitol is a fungal metabolite that has been found in Chaetomium and has antiviral activity.1 It inhibits replication of the influenza A subtype H3N2 with an EC50 value of 30 nM at a multiplicity of infection (MOI) of 0.01. It also inhibits replication of laboratory-adapted and clinical isolates of H3N2 (EC50s = 100 and 312 nM, respectively), as well as clinical isolates of the influenza A subtype H1N1 (EC50 = 417 nM). Aureonitol inhibits hemagglutination activity of H3N2 and H1N1.
1.Sacramento, C.Q., Marttorelli, A., Fintelman-Rodrigues, N., et al.Aureonitol, a fungi-derived tetrahydrofuran, inhibits influenza replication by targeting its surface glycoprotein hemagglutininPLoS One10(10)e0139236(2015)