Avenanthramide 1c

Avenanthramide 1c is a free radical scavenger and antioxidant. Avenanthramide 1c scavenges DPPH free radicals. Avenanthramide 1c inhibits azo-initiated linoleic acid peroxidation. Avenanthramide 1c exerts antioxidant effects. Avenanthramide 1c exhibits an antagonistic interaction with Avenanthramide 2f in the DPPH free radical scavenging system ^[1].

In Vitro, Avenanthramide 1c (0.50 mM) exhibits potent DPPH free radical scavenging activity in hydrophilic systems, with a ΔA value of 31 at 2 minutes^[1]. Avenanthramide 1c potently inhibits azo-initiated linoleic acid peroxidation in lipophilic systems, with a production slope of conjugated diene hydroperoxides of 1.0 μM/min within the first 30 minutes^[1]. Avenanthramide 1c (40-90 μM; 20 min) exhibits a significant antagonistic effect against Avenanthramide 2f in the DPPH free radical scavenging system (p = 0.02)^[1].

References:
[1]. Bratt K, et al. Avenanthramides in oats (Avena sativa L.) and structure-antioxidant activity relationships. J Agric Food Chem. 2003;51(3):594-600.
[2]. Sumayya PC, Babu GM, Muraleedharan K. Quantum chemical investigation of the antiradical property of avenanthramides, oat phenolics. Heliyon. 2021;7(2):e06125.