BMVC2 (Synonyms: o-BMVC) |
| カタログ番号GC63977 |
BMVC2 (o-BMVC) は、BMVC の二置換カルバゾール誘導体です。 BMVC2 は、G-四重鎖 (G4) スタビライザーです。
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Cas No.: 850559-51-2
Sample solution is provided at 25 µL, 10mM.
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BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer[1].
BMVC2 by monitoring the disappearance of the 291 nm CD signals of d[AG3(T2AG3)3] (HT22) after adding Cu2+ is screened, a longer unfolding time would dictate a better G4 stabilizer. The unfolding curve of HT22 in the presence of BMVC2 can be fitted by using two time constants of 133.7 s (29%) and 2816 s (71%), which are similar to the unfolding parameters of BMVC[1].
[1]. Jen-Fei Chu, et al. A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres. Journal of the Chinese Chemical Society, 2011, 58, 296-300.
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