Cinflumide is an orally active muscle relaxant. Cinflumide shows antiinflammatory activity [1].
In Vivo, Cinflumide (Compound 1) (i.p.; p.o.) is a potent, acting muscle relaxant in mice, exhibiting an ED50 of 63 mg/kg (i.p.)[1]. Cinflumide (p.o.) is a potent antiinflammatory agent in rats, with ED50 values of <20 mg/kg for reducing cell accumulation and edema, respectively, in the Carrageenan -induced pleurisy model[1].
References:
[1]. Musso DL, et al. Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity. J Med Chem. 2003 Jan 30;46(3):399-408.
In Vivo, Cinflumide (Compound 1) (i.p.; p.o.) is a potent, acting muscle relaxant in mice, exhibiting an ED50 of 63 mg/kg (i.p.)[1]. Cinflumide (p.o.) is a potent antiinflammatory agent in rats, with ED50 values of <20 mg/kg for reducing cell accumulation and edema, respectively, in the Carrageenan -induced pleurisy model[1].
References:
[1]. Musso DL, et al. Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity. J Med Chem. 2003 Jan 30;46(3):399-408.