Debio 0123 is an inhibitor of the checkpoint kinase WEE1 (IC50 = 0.8 nM).1 In vivo, debio 0123 (30 mg/kg per day), in combination with the inhibitor of topoisomerase II etoposide , reduces tumor volume in a patient-derived xenograft (PDX) mouse model of stomach cancer.2
References:
[1]. Hewitt, P., Burkamp, F., Wilkinson, A., et al.Pyrimidopyrimidones usefulL as WEE-1 kinase inhibitors(2018).
[2]. Rodrigo Imedio, E., Piggott, L., Bellon, A., et al.Methods OF treating small cell lung cancer(2023).