DMG-PEG2000-Mal-Cys-penetratin is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal maleimide (Mal). DMG-PEG2000-Mal-Cys-penetratin combines the membrane compatibility of lipids, the specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers ) by maleimide, and cell-penetrating peptides, making it suitable for research on biomaterial construction and drug delivery to cells.
In Vitro, The structure of DMG-PEG2000-Mal-Cys-penetratin comprises four key components, which work synergistically: DMG: As a hydrophobic anchor, it is responsible for firmly embedding the entire molecule into the membrane structure of lipid nanoparticles. PEG chain: As a hydrophilic spacer, it forms a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo. Maleimide: Located at the end of the PEG chain, it acts as a reaction interface, undergoing specific Michael addition reactions with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers) to achieve targeting or tracking functions. Cys-penetratin: Efficiently helps the entire nanoparticle cross the cell membrane and enter the cell to exert its effects.
In Vitro, The structure of DMG-PEG2000-Mal-Cys-penetratin comprises four key components, which work synergistically: DMG: As a hydrophobic anchor, it is responsible for firmly embedding the entire molecule into the membrane structure of lipid nanoparticles. PEG chain: As a hydrophilic spacer, it forms a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo. Maleimide: Located at the end of the PEG chain, it acts as a reaction interface, undergoing specific Michael addition reactions with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers) to achieve targeting or tracking functions. Cys-penetratin: Efficiently helps the entire nanoparticle cross the cell membrane and enter the cell to exert its effects.