DSPE-PEG2000-tetrazine is a synthetic phospholipid modified with PEG2000 and tetrazine moieties. DSPE-PEG2000-tetrazine gains improved steric stability via PEGylation. DSPE-PEG2000-tetrazine enables bioorthogonal click chemistry through its tetrazine segment, which selectively reacts with trans-cyclooctene ( TCO ) under complex biological environments. DSPE-PEG2000-tetrazine can be applied for researches related to click chemistry [1].
In Vitro, DSPE-PEG2000-tetrazine enables successful conjugation of Rhodamine-CRM197-TCO to PLGA/lipid hybrid nanoparticles via TCO-tetrazine click chemistry[1].
References:
[1]. Hu H, et al. Conjugation of Multiple Proteins Onto the Surface of PLGA/Lipid Hybrid Nanoparticles. J Biomed Mater Res A. 2025;113(1):e37807.
In Vitro, DSPE-PEG2000-tetrazine enables successful conjugation of Rhodamine-CRM197-TCO to PLGA/lipid hybrid nanoparticles via TCO-tetrazine click chemistry[1].
References:
[1]. Hu H, et al. Conjugation of Multiple Proteins Onto the Surface of PLGA/Lipid Hybrid Nanoparticles. J Biomed Mater Res A. 2025;113(1):e37807.