Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers.
Dp44mT (compound C7) (0-80 μM; 48 h) induces lytic cycle in cell line-dependent manner, with higher toxicity in AGS-BX1 than in AGS[1].Dp44mT (10 μM; 0-72 h) induces lytic cycle in a time-dependent manner[1].Dp44mT (1.25-2.5 μM; 24 h) cooperates with HDAC inhibitor Romidespin and SAHA to induce EBV lytic cycle[1].Dp44mT (20 μM; 48 h) leads to the EBV lytic cycle through induction of the ERK-autophagy axis[2].
References:
[1]. Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10(12):e0145994. [2]. Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505.