Ecamsule

Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .

Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm^[1].
Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment^[1].
.Ecamsule counteractes UV and AAPH induced ROS-formation^[1].
.The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%^[1].
.Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells^[1].

References:
[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244.
[2]. DeLeo VA, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.