GLP-1 (28-36) amide (trifluoroacetate salt) (Synonyms: Glucagon-like Peptide 1 (28-36) amide; Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2) |
| カタログ番号GC92088 |
グルカゴン様ペプチド1GLP-1 (28-36) amide (trifluoroacetate salt)は内因性GLP-1 RアゴニストGLP-1（7-36）アミドのペプチドと活性代謝物である。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Glucagon-like peptide 1 (GLP-1) (28-36) amide is a peptide and an active metabolite of the endogenous GLP-1R agonist GLP-1 (7-36) amide.1,2 It is formed from GLP-1 (7-36) amide by neprilysin (NEP).2 GLP-1 (28-36) amide (100 nM) inhibits decreases in ATP levels induced by hydrogen peroxide and increases in reactive oxygen species (ROS) levels induced by tert-butyl hydroperoxide (t-BHP) in primary mouse hepatocytes and H-4-II-E hepatoma cells.1 It reduces body weight gain, the ratio of weight gain to food intake, and hepatic gluconeogenesis in a mouse model of obesity induced by a high-fat diet (HFD) when administered at a dose of 18.5 nmol/kg per day.3 GLP-1 (28-36) amide decreases plasma levels of glucose and insulin and hepatic triglyceride levels in a mouse model of obesity induced by a very high-fat diet (VHFD) when infused at a rate of 18.5 nmol/kg per day.4
References:
[1]. Tomas, E., Stanojevic, V., and Habener, J.F.GLP-1-derived nonapeptide GLP-1(28-36)amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytesRegul. Pept.167(2-3)177-184(2011).
[2]. Hupe-Sodmann, K., McGregor, G.P., Bridenbaugh, R., et al.Characterisation of the processing by human neutral endopeptidase 2.
[4]. 11 of GLP-1(7-36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptidesRegul. Pept.58(3)149-156(1995).
[3]. Ip, W., Shao, W., Chiang, Y.-t.A., et al.GLP-1-derived nonapeptide GLP-1(28-36)amide represses hepatic gluconeogenic gene expression and improves pyruvate tolerance in high-fat diet-fed miceAm. J. Physiol. Endocrinol. Metab.305(11)E1348-E1358(2013).
[4]. Tomas, E., Wood, J.A., Stanojevic, V., et al.GLP-1-derived nonapeptide GLP-1(28-36)amide inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese miceRegul. Pept.169(1-3)43-48(2011).
| Cas No. | SDF | ||
| 同義語 | Glucagon-like Peptide 1 (28-36) amide; Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 | ||
| Chemical Name | L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl-L-argininamide, trifluoroacetate salt | ||
| Canonical SMILES | [H]N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)=O)CC3=CC=CC=C3.FC(F)(F)C(O)=O | ||
| Formula | C54H85N15O9 ? XCF3COOH | M.Wt | 1088.4 |
| 溶解度 | Acetonitrile: Slightly Soluble: 0.1-1 mg/ml,Chloroform: Slightly Soluble: 0.1-1 mg/ml,Methanol: Slightly Soluble: 0.1-1 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.9188 mL | 4.5939 mL | 9.1878 mL |
| 5 mM | 0.1838 mL | 0.9188 mL | 1.8376 mL |
| 10 mM | 0.0919 mL | 0.4594 mL | 0.9188 mL |
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Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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