Hericenone D, an orally active pancreatic lipase inhibitor, can be found in Hericium erinaceus. Hericenone D reduces lipid absorption and stimulates nerve growth factor NGF gene expression. Hericenone D can be used for the research of menopausal obesity [1] [2].
In Vivo, Hericenone D (~0.09 g/day; p.o.; 14 days) reduces white adipose tissue in the visceral and subcutaneous fat, decreases fat tissue around the uterus and the kidney and decreases the levels of total cholesterol and leptin in the plasma parameters of female C57BL/6JJcl mice[2]. Hericenone D (p.o.; 42 days) significantly reduces visceral and subcutaneous fat, decreases adipose tissue, increases lipid excreted from feces in female C57BL/6JJcl mice[2].
In Vitro, Hericenone D (3-100 μM; 24 h) does not exhibit significant neuroprotective activity against Tunicamycin or Thapsigargin -induced ER stress-dependent cell death in murine neuroblastoma Neuro2a cells[1]. Hericenone D (400 μg/mL; 30 min) exhibits significant pancreatic lipase inhibitory activity in a cell-free biochemical assay at a concentration of 400 μg/mL[2].
References:
[1]. Kobayashi S, et al. Total Synthesis, Structure Revision, and Neuroprotective Effect of Hericenones C-H and Their Derivatives. J Org Chem. 2021;86(3):2602-2620.
[2]. Hiraki E, et al. Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds. J Nat Med. 2017;71(3):482-491.
In Vivo, Hericenone D (~0.09 g/day; p.o.; 14 days) reduces white adipose tissue in the visceral and subcutaneous fat, decreases fat tissue around the uterus and the kidney and decreases the levels of total cholesterol and leptin in the plasma parameters of female C57BL/6JJcl mice[2]. Hericenone D (p.o.; 42 days) significantly reduces visceral and subcutaneous fat, decreases adipose tissue, increases lipid excreted from feces in female C57BL/6JJcl mice[2].
In Vitro, Hericenone D (3-100 μM; 24 h) does not exhibit significant neuroprotective activity against Tunicamycin or Thapsigargin -induced ER stress-dependent cell death in murine neuroblastoma Neuro2a cells[1]. Hericenone D (400 μg/mL; 30 min) exhibits significant pancreatic lipase inhibitory activity in a cell-free biochemical assay at a concentration of 400 μg/mL[2].
References:
[1]. Kobayashi S, et al. Total Synthesis, Structure Revision, and Neuroprotective Effect of Hericenones C-H and Their Derivatives. J Org Chem. 2021;86(3):2602-2620.
[2]. Hiraki E, et al. Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds. J Nat Med. 2017;71(3):482-491.