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Histatin-3 TFA

カタログ番号GC72254 Copy One-Click Copy Product Info

Histatin-3 TFAは32個のアミノ酸からなるペプチドであり、強力な抗菌性能を有する。

Products are for research use only. Not for human use. We do not sell to patients.

Histatin-3 TFA 化学構造

Cas No.: 112844-49-2

サイズ 価格 在庫数 個数
1 mg
$45.00
在庫あり
5 mg
$135.00
在庫あり
10 mg
$225.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com


顧客レビュー

カスタマーレビューに基づきます。

Sample solution is provided at 25 µL, 10mM.



Description of Histatin-3 TFA

Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM.

References:
[1]. A Basak, et al. Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1. J Pept Res. 1997 Jun;49(6):596-603.

Chemical Properties of Histatin-3 TFA

Cas No. 112844-49-2 SDF
Formula C178H258N64O48.xC2HF3O2 M.Wt 4062.35 (free acid)
溶解度 H2O : 50 mg/mL (Need ultrasonic) Storage Sealed storage, away from moisture and light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Histatin-3 TFA

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 246.2 μL 1.2308 mL 2.4616 mL
5 mM 49.2 μL 246.2 μL 492.3 μL
10 mM 24.6 μL 123.1 μL 246.2 μL
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In vivo Formulation Calculator (Clear solution) of Histatin-3 TFA

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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