HP661 |
カタログ番号GC91057
One-Click Copy Product Info
|
ミトコンドリア複合体I阻害剤
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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HP661 is an inhibitor of mitochondrial complex I, also known as NADH dedrogenase.1 It is selective for complex I, inhibiting it by 77.6%, over complex III, which it inhibits by 28.1%, and complexes II and IV, which it does not inhibit, at 1 µM. HP661 selectively reduces viability of the human lung cancer cells H460, NCI H441, and trametinib-resistant A549 cells (IC50s = 10.6, 29.7, and 15.1 nM, respectively), which all have high levels of oxidative phosphorylation, over NCI H358 human lung cancer cells (IC50 = >10,000 nM), which have low levels of oxidative phosphorylation, and non-cancerous human pancreatic normal epithelial (HPNE) and MRC-5 human fetal lung fibroblast cells (IC50s = >10,000 nM for both). HP661 reduces tumor volume in an H460 mouse xenograft model when administered at a dose of 30 mg/kg twice per day and has an additive effect on trametinib-induced reduction of tumor growth.
| Cas No. | SDF | ||
| Formula | C31H29F6N7O3 | M.Wt | 661.6 |
| 溶解度 | Chloroform: Soluble,Methanol: Soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5115 mL | 7.5574 mL | 15.1149 mL |
| 5 mM | 302.3 μL | 1.5115 mL | 3.023 mL |
| 10 mM | 151.1 μL | 755.7 μL | 1.5115 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A crystalline solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)