Leucomycin A1 (Synonyms: Kitasamycin A1,3-deacetyl Josamycin,Leucomycin V 4-isovalerate,9-dihydro Niddamycin,Turimycin H5) |
カタログ番号GC10414
One-Click Copy Product Info
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マクロライド系抗生物質の主要代謝産物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 16846-34-7
Sample solution is provided at 25 µL, 10mM.
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Leucomycin A1, a major metabolite extracted from the leucomycin complex, is a major macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis.
Leucomycin A1 is one of the more potent members of leucomycin complex. Leucomycin complex (kitasamycin) is effective against a wide spectrum of pathogens, such as Gram-positive bacteria, Gram-negative cocci, mycoplasma, and Leptospira. Leucomycin complex has been used as an animal health product for control of Gram positive bacteria, Gram negative cocci, mycoplasma, and Leptospira. Until now, little is known about the activity of individual analogues within the complex. At a concentration of 1.56μg/ml, kitasamycin inhibited all isolates of Diplococcus pneumonia [2]. Each component of leucomycins potently inhibited the growth of Gram-positive bacteria and showed not so strong activity against the Gram-negative bacteria. Each component showed the same tendency towards the antibacterial spectrum [3].
References:
[1] Hata T, Sano Y, Ohki N, et al. Leucomycin, a new antibiotic[J]. The Journal of antibiotics, 1953, 6(2): 87-89.
[2] Balducci Y, BODEY G P. In vitro activity of kitasamycin against gram-positive cocci[J]. The Journal of antibiotics, 1974, 27(7): 516-519.
[3] Omura S, Katagiri M, Umezawa I, et al. Structure-biological activities relationships among leucomycins and their derivatives[J]. The Journal of antibiotics, 1968, 21(9): 532-538.
| Cas No. | 16846-34-7 | SDF | |
| 同義語 | Kitasamycin A1,3-deacetyl Josamycin,Leucomycin V 4-isovalerate,9-dihydro Niddamycin,Turimycin H5 | ||
| Chemical Name | 4B-(3-methylbutanoate) leucomycin V | ||
| Canonical SMILES | O=C1C[C@H]([C@@H]([C@H]([C@H](C[C@H]([C@H](/C=C/C=C/C[C@H](O1)C)O)C)CC=O)O[C@@]2(O[C@@H]([C@H]([C@@H]([C@H]2O)N(C)C)O[C@]3(C[C@@](O)([C@H]([C@@H](O3)C)OC(CC(C)C)=O)C)[H])C)[H])OC)O | ||
| Formula | C40H67NO14 | M.Wt | 786 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.2723 mL | 6.3613 mL | 12.7226 mL |
| 5 mM | 254.5 μL | 1.2723 mL | 2.5445 mL |
| 10 mM | 127.2 μL | 636.1 μL | 1.2723 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)