Ligustroside |
| カタログ番号GC63973 |
セコイリドイド誘導体であるリグストロシド (リグストロシド) は、初期アルツハイマー病 (AD) のモデルにおけるミトコンドリアの生体エネルギーと、Aβ 産生を妨げない可能性のあるメカニズムによる脳の老化に対して優れた性能を発揮します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 35897-92-8
Sample solution is provided at 25 µL, 10mM.
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Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer’s disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages[1][2].
Ligstroside increases mRNA expression of SIRT1, CREB1, complex I, and GPx1 in SH-SY5Y-APP695 cells[1].
Ligstroside (50 mg/kg; a supplemented diet for 6 months) protects against mitochondrial dysfunction in models of early Alzheimer’s disease and brain ageing[1].
[1]. Grewal R, et al. Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer’s disease and brain ageing. Exp Neurol. 2020;328:113248. [2]. Liu J, et al. Chemical structures of constituents from the flowers of Osmanthus fragrans var. aurantiacus. J Nat Med. 2015;69(1):135-141.
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