N-Myristoyl-D-asparagine is a key metabolic marker in the biosynthesis and maturation of colibactin. N-Myristoyl-D-asparagine acts as a biomarker for detecting colibactin. N-Myristoyl-D-asparagine exhibits mild growth inhibitory activity against Bacillus subtilis NCIB 3610 [1] [2].
In Vitro, N-Myristoyl-D-asparagine is released during colibactin maturation and serves as a biomarker for colibactin production by Escherichia coli Nissle and related strains[1]. N-Myristoyl-D-asparagine is a prodrug precursor fragment cleaved from the putative colibactin precursor by the peptidase ClbP[2].
References:
[1]. Kalantari A, et al. Robust performance of a live bacterial therapeutic chassis lacking the colibactin gene cluster. PLoS One. 2023;18(2):e0280499. Published 2023 Feb 2.
[2]. Bian X, et al. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety. Chem Sci. 2015 May 1;6(5):3154-3160.
In Vitro, N-Myristoyl-D-asparagine is released during colibactin maturation and serves as a biomarker for colibactin production by Escherichia coli Nissle and related strains[1]. N-Myristoyl-D-asparagine is a prodrug precursor fragment cleaved from the putative colibactin precursor by the peptidase ClbP[2].
References:
[1]. Kalantari A, et al. Robust performance of a live bacterial therapeutic chassis lacking the colibactin gene cluster. PLoS One. 2023;18(2):e0280499. Published 2023 Feb 2.
[2]. Bian X, et al. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety. Chem Sci. 2015 May 1;6(5):3154-3160.