NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that bind to proteins in separate cellular compartments that can induce nuclear import of cytosolic cargoes, using nuclear-localized bromodomain-containing protein 4 (BRD4) as a “carrier” for co-import and nuclear trapping of cytosolic proteins.
References:
[1]. William J. Gibson, et al. Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. Version 1. bioRxiv. Preprint. 2023 Jul 7.