NS 3861 |
カタログ番号GC91913
One-Click Copy Product Info
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NS 3861はニューロンニコチン型アセチルコリン受容体（nAChR）アゴニストである。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 216853-59-7
Sample solution is provided at 25 µL, 10mM.
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NS 3861 is a neuronal nicotinic acetylcholine receptor (nAChR) agonist.1 It induces inward currents in patch-clamp assays using X. laevis oocytes expressing recombinant human α3β2- or α3β4 subunit-containing nAChR receptors (EC50s = 1.6 and 1 ?M, respectively). In vivo, NS 3861 (0.1 mg/kg) increases the number of fecal pellets expelled in mice exposed to long-term, but not short-term, morphine injections.2
References:
[1]. Harps?e, K., Hald, H., Timmermann, D.B., et al.Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptorsJ. Biol. Chem.288(4)2559-2570(2013).
[2]. Gade, A.R., Kang, M., Khan, F., et al.Enhanced sensitivity of α3β4 nicotinic receptors in enteric neurons after long-term morphine: Implication for opioid-induced constipationJ. Pharmacol. Exp. Ther.357(3)520-528(2016).
| Cas No. | 216853-59-7 | SDF | |
| Chemical Name | 3-(3-bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene | ||
| Canonical SMILES | CN1C2CC(C3=C(Br)C=CS3)=CC1CC2 | ||
| Formula | C12H14BrNS | M.Wt | 284.2 |
| 溶解度 | DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.5186 mL | 17.5932 mL | 35.1865 mL |
| 5 mM | 703.7 μL | 3.5186 mL | 7.0373 mL |
| 10 mM | 351.9 μL | 1.7593 mL | 3.5186 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)