PTIO is a nitric oxide-selective capture agent that can react with nitric oxide to form the corresponding •NO2 and imino nitroxides [1]. PTIO can enhance the oxidation effect of permanganate on organic pollutants, inhibit the self-coupling of bisphenol A (BPA), and promote the oxidation decomposition [2]. PTIO has been widely used as a reactivity model of reactive oxygen species in the development of in vitro antioxidant activity measurement methods, and has been employed to effectively analyze the structure-activity relationship of antioxidants[3].
References:
[1] Goldstein S, Russo A, Samuni A. Reactions of PTIO and carboxy-PTIO with· NO,· NO2, and O 2.¯[J]. Journal of Biological Chemistry, 2003, 278(51): 50949-50955.
[2] Zhao L, Zhang J, Ma J. PTIO as a redox mediator to enhance organic contaminants oxidation by permanganate[J]. Water Research, 2023, 244: 120500.
[3] Li X. 2-Phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO•) radical scavenging: A new and simple antioxidant assay in vitro[J]. Journal of agricultural and food chemistry, 2017, 65(30): 6288-6297.