Pyrocatechol sulfate TEA is a dietary phenolic metabolite and uremic toxin. Pyrocatechol sulfate TEA can be derived from diet and gut Bacterial metabolism. Plasma levels of Pyrocatechol sulfate TEA are sensitive to alcohol exposure and withdrawal, and are negatively correlated with anxiety, depression, and craving for alcohol in severe alcohol use disorder. Pyrocatechol sulfate TEA can be used in studies related to chronic kidney disease and severe alcohol use disorder [1] [2].
In Vivo, Pyrocatechol sulfate TEA accumulates in the plasma, liver, heart and kidney tissues of rats with chronic kidney disease, with a plasma-tissue level correlation[1].
References:
[1]. Velenosi TJ, et al. Untargeted plasma and tissue metabolomics in rats with chronic kidney disease given AST-120. Sci Rep. 2016 Mar 2;6:22526.
[2]. Leclercq S, et al. Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder. Elife. 2024 Nov 29;13:RP96937.
In Vivo, Pyrocatechol sulfate TEA accumulates in the plasma, liver, heart and kidney tissues of rats with chronic kidney disease, with a plasma-tissue level correlation[1].
References:
[1]. Velenosi TJ, et al. Untargeted plasma and tissue metabolomics in rats with chronic kidney disease given AST-120. Sci Rep. 2016 Mar 2;6:22526.
[2]. Leclercq S, et al. Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder. Elife. 2024 Nov 29;13:RP96937.