(Rac)-LRK-4189 is the racemate of LRK-4189. LRK-4189 (Compound 603) is an orally active and selective PIP4K2C PROTAC degrader with a DC50 < 500 nM for PIP4K2C in MOLT-4 cells. LRK-4189 has an antitumor activity and induces intrinsic cell death and activates interferon signaling, therefore triggering immune-mediated tumor killing in immune-inert microsatellite stable (MSS) CRC cells. LRK-4189 can be used for cancers like MSS colorectal carcinoma research [1].
References:
[1]. Krista Goodman, et al. Discovery of LRK-4189, a first-in-class degrader of the lipid kinase PIP4K2C for the treatment of Microsatellite Stable (MSS) Colorectal Carcinoma. ACS. 2025 Aug 20.
References:
[1]. Krista Goodman, et al. Discovery of LRK-4189, a first-in-class degrader of the lipid kinase PIP4K2C for the treatment of Microsatellite Stable (MSS) Colorectal Carcinoma. ACS. 2025 Aug 20.