rel-Biotin-d4 is a deuterium-labeled biotin (vitamin B7) isotopic compound. rel-Biotin-d4 can serve as a coenzyme for multiple carboxylases, participating in the carboxylation process as a CO₂ carrier in carboxylase reactions, while functioning as a tracer and an internal standard in NMR, GC-MS, or LC-MS analyses for quantitative analysis. rel-Biotin-d4 can be used for related research in metabolic studies, exploration of enzymatic reaction mechanisms, and pharmacokinetics and metabolic profiling during drug development[1-3].
References:
[1] Russak EM, Bednarczyk EM. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
[2] Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem. 1999 Mar;10(3):128-38.
[3] Mock DM. Biotin status: which are valid indicators and how do we know? J Nutr. 1999 Feb;129(2S Suppl):498S-503S.