REM127 is a small molecule compound capable of modulating calcium homeostasis in cells and possesses neuroprotective effects. REM127 can restore the calcium homeostasis imbalance in cellular models caused by pathological accumulation of tau protein. REM127 can efficiently cross the blood-brain barrier, and it has the potential to rescue synaptic and cognitive deficits in Alzheimer's disease animal models, as well as to slow down the progression of amyloid-beta and tau protein pathologies. REM127 can be used for research in neurodegenerative diseases.
References:
[1]. Princen K, et al. Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer’s disease[J]. Science, 2024, 384(6699): eadd6260.