S-Adenosyl-3-thiopropylamine acts as a weak to moderate reversible inhibitor of spermidine/spermine synthase, and its inhibitory activity increases after oxidation (to S-Adenosyl-3-thiopropylamine sulphoxide and S-Adenosyl-3-thiopropylamine sulphone) [1].
In Vitro, S-Adenosyl-3-thiopropylamine (0.1-1 mM; 30 min) inhibits purified rat ventral prostate spermidine synthase (55% inhibition at 1 mM) and spermine synthase (65% inhibition at 1 mM), with weak activity at 0.1 mM[1].
References:
[1]. Hibasami H, et al. Studies of inhibition of rat spermidine synthase and spermine synthase. The Biochemical journal. 1980 May 01;187(2):419-28.
In Vitro, S-Adenosyl-3-thiopropylamine (0.1-1 mM; 30 min) inhibits purified rat ventral prostate spermidine synthase (55% inhibition at 1 mM) and spermine synthase (65% inhibition at 1 mM), with weak activity at 0.1 mM[1].
References:
[1]. Hibasami H, et al. Studies of inhibition of rat spermidine synthase and spermine synthase. The Biochemical journal. 1980 May 01;187(2):419-28.