Selovoxolone (CKBA), a derivative of AKBA is an inhibitor of acetyl-CoA carboxylase 1 ( ACC1 ), with an IC50 of 5.02 μM. Selovoxolone inhibits the differentiation of Th17 cells and has IC50 values of 3.28 μM for mouse cells and 3.61 μM for human cells. Selovoxolone ointment significantly alleviates psoriasis-like inflammation in mice. Selovoxolone can be used for the study of psoriasis [1].
References:
[1]. Lou F, et al. Identification and pre-clinical investigation of 3-O-cyclohexanecarbonyl-11-keto-β-boswellic acid as a drug for external use to treat psoriasis. Br J Pharmacol. 2024 Apr;181(8):1290-1307.
References:
[1]. Lou F, et al. Identification and pre-clinical investigation of 3-O-cyclohexanecarbonyl-11-keto-β-boswellic acid as a drug for external use to treat psoriasis. Br J Pharmacol. 2024 Apr;181(8):1290-1307.