Sialyl Lewis A (SLeA) sodium is a tumor-associated carbohydrate antigen, also known as carbohydrate antigen 19-9 (CA19-9), that binds to E-selectin (ELAM-1) and selectins to mediate cell-endothelium adhesion. Sialyl Lewis A sodium promotes cancer cell-vascular endothelium adhesion, and its surface presence correlates with increased tumorigenicity and invasiveness in cancer cells. Sialyl Lewis A sodium shows elevated expression in human adenocarcinomas of the colon, pancreas, and stomach, with expression levels linked to tumor progression and poor prognosis in colorectal and gastric carcinomas. Sialyl Lewis A sodium can be used for the research of cancers, such as colon, pancreas, stomach, and squamous lung cancer [1] [2] [3].
In Vitro, Sialyl Lewis A sodium mediates adhesion of human colon, pancreas, and gastric cancer cells to E-selectin-expressing endothelial cells, with complete abolition of this adhesion when Sialyl Lewis A sodium expression is suppressed via antisense FT III cDNA transfection[1]. Sialyl Lewis A sodium mediates adhesion of human urinary bladder cancer Hu 1703He cells to E-selectin-expressing CHO cells[1]. Sialyl Lewis A sodium expression is required for the tumorigenicity of human squamous lung cancer cells in athymic nu/nu nude mice[1]. Sialyl Lewis A sodium mediates nearly exclusive ELAM-1-dependent adhesion of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines to rIL1β-activated HUVECs[2]. Sialyl Lewis A sodium is strongly expressed on the surface of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines, but is not detected on any of the 12 tested human leukemia cell lines[2]. Sialyl Lewis A sodium does not contribute to the adhesion of any of the 12 tested human leukemia cell lines to rIL1β-activated HUVECs[2].
References:
[1]. Ugorski M, et al. Sialyl Lewis a: a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells[J]. Acta Biochimica Polonica, 2002, 49(2): 303-311.
[2]. Takada A, et al. Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium[J]. Cancer research, 1993, 53(2): 354-361.
[3]. Ma Z, et al. Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages. Front Immunol. 2021 May 31;12:679424.
In Vitro, Sialyl Lewis A sodium mediates adhesion of human colon, pancreas, and gastric cancer cells to E-selectin-expressing endothelial cells, with complete abolition of this adhesion when Sialyl Lewis A sodium expression is suppressed via antisense FT III cDNA transfection[1]. Sialyl Lewis A sodium mediates adhesion of human urinary bladder cancer Hu 1703He cells to E-selectin-expressing CHO cells[1]. Sialyl Lewis A sodium expression is required for the tumorigenicity of human squamous lung cancer cells in athymic nu/nu nude mice[1]. Sialyl Lewis A sodium mediates nearly exclusive ELAM-1-dependent adhesion of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines to rIL1β-activated HUVECs[2]. Sialyl Lewis A sodium is strongly expressed on the surface of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines, but is not detected on any of the 12 tested human leukemia cell lines[2]. Sialyl Lewis A sodium does not contribute to the adhesion of any of the 12 tested human leukemia cell lines to rIL1β-activated HUVECs[2].
References:
[1]. Ugorski M, et al. Sialyl Lewis a: a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells[J]. Acta Biochimica Polonica, 2002, 49(2): 303-311.
[2]. Takada A, et al. Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium[J]. Cancer research, 1993, 53(2): 354-361.
[3]. Ma Z, et al. Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages. Front Immunol. 2021 May 31;12:679424.